In HHH patients, TNF-α was significantly correlated with IL-10 (r2 = 0.819, p < 10−10), IL-1β (r2 = 0.679, p < 10−7), and IL-8 (r2 = 0.530, p < 10−5). This evidence concerns the gene CXCL8 and ornithine translocase deficiency.