VEGFA and macular retinal edema: The first line treatment is the hyperglicemia control, accompanied by monitoring of blood pressure and lipid levels [68, 69], which permits the disappearance of macular edema in about 33% to 35% of patients [7, 8], in the other 70% of cases a treatment in the remaining 70% of cases we must establish a treatment based on laser photocoagulation or intravitreal injections of anti-VEGF.