At the top of Figure 1, SNPs rs7577262 (TRPM8), rs11172113 (LRP1), rs6478241 (ASTN2), rs10915437 (near AJAP1), and rs9349379 (PHACTR1) form a cluster with relatively less pronounced differences in association by stratum status of the migraine-associated characteristics. The gene discussed is TRPM8; the disease is migraine disorder.