TSPAN2 and Photophobia: For example, rs12134493 (near TSPAN2), which is highly selective for migraine with attack frequency ≥6/year, also shows selectivity for unilateral pain, phonophobia, and photophobia, but not for pulsation, duration of 4–72 hours, aggravation by physical activity, and inhibition of daily activities, all features that show selective association with other SNPs, including SNPs that are also selective for high frequency migraine.