In a previous study, acute administration of 10 mg/kg vortioxetine to PCPA-treated rats lead to functionally relevant occupancies of 5-HT1A and 5-HT1B receptors (43 and 89%, respectively), and recovery of memory impairment in the object recognition and spontaneous alternation tests (du Jardin et al., 2014). The gene discussed is HTR1A; the disease is memory impairment.