Several ND10 constituent proteins, including PML (promyelocytic leukemia), Sp100 (speckled protein of 100 kDa), hDaxx (human death domain-associated protein 6), and ATRX (alpha thalassemia/mental retardation syndrome X-linked) can limit the replication of an ICP0 null HSV-1 mutant [41,42,43]. The gene discussed is DAXX; the disease is alpha thalassemia spectrum.