As to confirm the epigenetic nature of the therapy, a higher immunoreaction positivity for DNMT3b (DNA methyltransferase 3b) was found in tumour cells nuclei of control animals, (15.7% positivity of a cumulative number of 595 cells, Table 1) (Fig. 7 panel B, CTRL), and in animals treated with 120 ng free 5-Aza-2'-dC (14.7%, of 651 cells; Fig. 7 panel B, A2) as compared to animals treated with A-EMHVs in presence of MF (10.4% of 619 cells; Fig. 7 panel B, A-EMHVs-MF). Here, DNMT3B is linked to neoplasm.