Remarkably, all four mIMCD-3 cell lines stably expressing hICD formed cyst-like structures (hICD3, 6, 13, 100%; hICD5, <100%), in striking contrast to all four empty vector-transfected control cell lines (CTL1, 2, 3, 4, 100%) which formed tubule-like structures irrespective of the absence or presence of hepatic growth factor (HGF) (Figure 2A). The gene discussed is HGF; the disease is cyst.