Hierarchical two-way clustering (average distance metric for over expressed genes) of the Oncomine data exhibited a subcluster of diagnostic classes for Activated B-Cell-Like DLBCL and Germinal Center B-Cell-Like DLBCL that over expressed SYK, DAD1, HSPA5 and CYR61 and additional 2 classes (CLL and DLBCL) that overex-pressed both SYK and CYR61 (Figure 1). The gene discussed is HSPA5; the disease is diffuse large B-cell lymphoma.