Manciniet al. in their prospective case-control studyon 44 patients showed that homocysteine levelsdid not differ among PCOS women and controls.In this study, they also assessed androgens, fastingglucose, insulin, leptin, fibrinogen, homocysteine,endothelin-1 and flow-mediated dilatation of thebrachial artery to investigate their relationshipsto weight and PCOS. This evidence concerns the gene EDN1 and polycystic ovary syndrome.