It has been concluded thatPCOS in adolescents is similar to adults and thatit is clearly associated with menstrual dysfunctionand/or high androgen and LH levels, but the relationshipwith hirsutism and acne is less clear (17).It should be noted that hormonal evaluation andovarian sonography were not performed in our subjectsbased on the statements that clinical examinationis more diagnostic than polycystic-appearingovaries as seen with sonography in the adolescentpopulation (10, 14) . The gene discussed is PLOD1; the disease is acne.