DNA methylation is a major epigenetic mechanism that has an important role in chromosomal stability and gene expression in mammalian cells.6-8 Aberrant promoter methylation of tumor suppressor genes is closely related with loss of their function.9,10 DNA methyltransferases, of which three active forms have been identified (DNMT1, DNMT3A and DNMT3B) catalyze DNA methylation. Here, DNMT3B is linked to neoplasm.