Ischemia in the gastrointestinal tract is another peripheral vascular disorder associated with IFN therapy in HCV-infected patients.52 Leung et al.53 have reported an interesting case of ischemic colitis that developed 34 weeks after PEG-IFN-alpha; the patient’s symptoms rapidly resolved with the cessation of therapy. This evidence concerns the gene IFNA1 and ischemic colitis.