CDKN2B-AS1 and coronary artery disorder: TEs can also contribute DNA-binding domains to lncRNA (Type IIb in Fig. 2): A recent study of the coronary artery disease-associated lncRNA, ANRIL, showed that Alu elements within its sequence were necessary for its biological activity; and loss of embedded Alu elements reversed ANRIL's promotion of growth, adhesion, and motility in cell models (Holdt et al. 2013).