In our study, we found that systemic levels of IL-6, IL-8, IL-10, and TNFα show potential as diagnostic markers for the detection of pancreatic adenocarcinoma (with sensitivity and specificity of approximately 70–80%), whereas IL-23 concentrations could potentially be used to exclude a diagnosis of pancreatic cancer in humans. This evidence concerns the gene CXCL8 and pancreatic neoplasm.