While IQGAP3 expression in normal tissues was restricted to the colon, small intestine and testis, high levels of IQGAP3 mRNA were observed in a number of tumors including lung cancer, hepatocellular carcinoma, renal cancer, gastric cancer, bladder cancer, colon cancer and leukemia (data not shown). This evidence concerns the gene IQGAP3 and colonic neoplasm.