TNF and Hepatic fibrosis: Decreased release of TNF-α from Kupffer cells and recruited macrophages could be one of the mechanisms for the suppression of diet-induced steatohepatitis in Nrd1−/− mice, and thus nardilysin in Kupffer cells and recruited macrophages may be required for the progression of NASH and liver fibrosis, concomitantly with the recruitment of myofibroblasts.