We examined the role of nardilysin, that is known to enhance TNF-α shedding, in the development of steatohepatitis using Nrd1+/+ and Nrd1−/− mice fed a choline-deficient and amino acid-defined (CDAA) diet and a high-fat diet (HFD), that are used widely to reproduce the natural course of NASH and liver fibrosis in mice as well as in humans. Here, TNF is linked to Hepatic fibrosis.