In humans, single amino acid mutations in RyR2 lead to life-threatening cardiac arrhythmias, also as demonstrated by the ~160 mutations that have been linked so far to catecholaminergic polymorphic ventricular tachycardia (CPVT; Priori and Chen, 2011). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.