CAMK2G and heart disorder: RyR2 may be phosphorylated in vitro and in vivo by several kinases, but here we will concentrate on CaMKIIδ (the most abundant CaMKII expressed in the heart and referred to here simply as “CaMKII”), and incorporate protein kinase A (PKA) whenever relevant, as these two kinases share some common transduction pathways, bear the most relevance in cardiac diseases and have been studied the most.