Prominent brain iron accumulation eventually with cerebellar atrophy can be the main neuroradiological sign in atypical INAD whereas non-specific changes such as cerebral atrophy are reported for individuals with PLA2G6-related dystonia-parkinsonism (Kurian and Hayflick, 2013). This evidence concerns the gene PLA2G6 and neurodegeneration with brain iron accumulation 2A.