Similar results were also recently obtained by Hashimoto et al. (2012) who reported that the levels of Aβ oligomers in APOE ε4/ε4 AD brains were 2.7 times higher than those found in APOE ε3/ε3 AD brains, and that ApoE increased Aβ oligomer levels in an isoform-dependent manner (E2 < E3 < E4). Here, APOE is linked to Alzheimer disease.