APP and infection: Ruth Itzhaki’s group found that in human SH-SY5Y neuroblastoma cells HSV-1 induces APP cleavage with the production of a 55-kDa fragment (recognized in Western blot analysis by an anti-C-terminal APP antibody) starting from 6 h post infection (hpi), and the concomitant reduction of band intensity relative to full-length APP (Shipley et al., 2005).