TF and peripheral arterial disease: According to these epidemiological studies, high systemic iron levels, monitored by serum ferritin levels or transferrin saturation, positively correlated with increased risk of myocardial infarction (Salonen et al., 1992; Morrison et al., 1994; Tuomainen et al., 1998; Holay et al., 2012) cardiovascular disease (Rajapurkar et al., 2011), peripheral arterial disease (PAD) (Menke et al., 2009), and mortality rates (Lauffer, 1990).