HOMER1 and Cognitive impairment: Both group 1 mGluR function and Homer 1 expression have been associated with stress-induced cognitive deficits (Tronson et al., 2010; Menard et al., 2013; Wagner et al., 2013), and anxious behaviors are exacerbated by aging in the mGluR5−/− mice (Inta et al., 2013).