Therefore, pathological conditions that reduce Cx36 GJC and expression, such as Borna disease virus (Koster-Patzlaff et al., 2009), Huntington’s disease (Petrasch-Parwez et al., 2004), and inflammation (Dobrenis et al., 2005) have the potential to hinder synaptic plasticity. Here, GJD2 is linked to juvenile Huntington disease.