CLU and Alzheimer disease: Given the significance of cholesterol in AD pathology [29]–[32], it is of relevance that some of the transcripts involved in cholesterol metabolism were either markedly increased (i.e. Apoe, Clu and Lrp6), decreased (i.e. Abca1) or remained unaltered (i.e. Apoa1, Lpl, Lrp1 and Lrp8) in MS9II cells compared to MS cells (Figs. 1A; 5A, B, E and F).