A number of studies, however, indicate that IGF-II receptor can mediate certain biological effects of IGF-II in multiple cell types, including stimulation of calcium influx in Balb/c-3T3 fibroblasts and CHO cells [36], motility of human rhabdomyosarcoma cells [37], migration of human extravillous trophoblasts [71], stimulation of Na+/H+ exchange and inositol trisphosphate production [38] and insulin exocytosis by pancreatic β cells [72]. Here, IGF2 is linked to rhabdomyosarcoma.