Induction of HO-1 by proton pump inhibitors was first reported by Becker et al [5], who found that both lansoprazole and omeprazole up-regulated the mRNA, IR and activity of HO-1 in human gastric cancer cells (AGS cells and KATO cells), RGM-1 cells and human endothelial cells (ECV304). This evidence concerns the gene HMOX1 and gastric cancer.