TCF7L2 and type 2 diabetes mellitus: Risk alleles of all of the 49 investigated T2D loci were associated with incident diabetes with HRs for T2D ≥1, with effect sizes ranging from 1.01 for ADAMTS9 to 1.33 for TCF7L2 per risk allele (Table 2) and p-values <0.05 for 35 of the loci.