PAPSS2 and bone disorder: A perturbation of matrix assembly has previously been reported in association with mutant PAPSS2. Chondrodysplasias, severe bone disorders, are associated with mutations in PAPSS2 and SLC26A2 and lead to reduced sulphate uptake, undersulphation of GAGs, and defective FN matrix assembly in cells (Ikeda et al, 2001; Galante & Schwarzbauer, 2007).