APOBEC3B and cancer: Numerous recent studies support a role for the TpC preferring APOBEC C deaminases, especially APOBEC3B, in generating large numbers of mutations (i.e., the ‘mutator phenotype’ [Bielas et al., 2006; Venkatesan et al., 2006]) that characterize the progression, and perhaps initiation, of cancers (Nik-Zainal et al., 2012; Roberts et al., 2012; Stephens et al., 2012; Burns et al., 2013; Leonard et al., 2013; Roberts et al., 2013; Taylor et al., 2013).