In contrast, despite the persistent DNA damage caused by the impaired DDR, SETD2 mutant ccRCC cells (RCC-MF and RCC-FG2) evaded the cell cycle checkpoint as revealed by the low levels of p53 phosphorylation and unnoticeable change of its total protein levels (Figure 8A). This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.