SETD2 and nonpapillary renal cell carcinoma: SETD2 mutations were recently found in several cancers, such as clear cell renal cell carcinoma (ccRCC) (Dalgliesh et al., 2010; Duns et al., 2010; Varela et al., 2011; Zhang et al., 2012; Fontebasso et al., 2013; Joseph et al., 2014).