FUS and neuroblastoma: The prion domain of an yeast protein Sup35 does not form aggregates when expressed in neuroblastoma cells (data not shown), but its addition to the CT fragment of FUS (Sup35-FUS construct, Fig. 3A) was sufficient to restore aggregation capacity—like full-length FUS this fusion protein formed granules and large aggregates, and was recovered in insoluble fraction (Fig. 3B and D).