IL-6Rα-deficient CD4+ CD45RBhi T cells failed to induce colitis when transferred into RAG2 KO mice (Figure 1—figure supplement 3A–C) and compared to WT mice, IL-6RαT-KO mice were also resistant to the induction of EAE following immunization with MOG35-55/CFA (Figure 1—figure supplement 3D). The gene discussed is RAG2; the disease is colitis.