VEGFA and sarcoma: The ability of HT-1080 cells to form aggressive angiogenic tumors in xenograft mouse models [38], their high level of secreted VEGF-A and the up-regulation of hypoxia-related genes observed in different human sarcoma tumors [39], led us to investigate the potential in vitro effects of SEN461 treatment on tubule-formation by the hypoxia-primed cells.