NFKB1 and Parkinson disease: The existence of ongoing inflammatory processes that may contribute to the progression of PD is supported, e.g., by the presence of activated microglia, the accumulation of cytokines and nuclear factor kappa B (NF-κB) pathway activation in the cerebrospinal fluid and the brain of PD patients (Hirsch and Hunot 2009; McGeer et al. 1988).