There were a number of pathways that were significant by 1 hour and remained significant following both LPS and Pam3CSK4 stimulations: “TNFR2 signalling”, “TREM1 signalling”, Altered T cell and B Cell signalling in Rheumatoid arthritis” and “Dendritic cell maturation” pathways. Here, TNFRSF1B is linked to rheumatoid arthritis.