Activation of TLR4 sensitizes hepatic stellate cells toward the effects of TGF-β and thereby promotes TGF-β dependent activation and collagen production.TLR4-deficient mice were protected against hepatic fibrosis in three different models of experimental liver disease, demonstrating that TLR4 signalling is required for TGF-β-dependent hepatic fibrosis [23]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.