In CAD, no alterations in γδT cell counts have been reported to date, but decreases in CD3+ lymphocytes and increases of IFN–γ secreting CD8+CD56+ T lymphocytes and of CD28—CD4+ T lymphocytes - also a significant source of IFN–γ - have been reported [15]–[17]. The gene discussed is CD28; the disease is coronary artery disorder.