It is an interesting possibility that fibrinogen/fibrin competes with proteins such as fibronectin and matrix metalloproteinase-1 for the same binding site on collagen fibres, i.e. the binding site defined by the peptide II-44; such a competition will attribute an ECM-modulating role of fibrin deposited in tissues during inflammation, carcinoma and healing wounds. This evidence concerns the gene FN1 and carcinoma.