A single case has been reported in the literature demonstrating activity of Pazopanib (Votrient®, GlaxoSmithkline, Brentford, UK), an oral multikinase inhibitor against VEGFR, PDGFR and KIT, in a patient with metastatic MCC that progressed after cytotoxic therapy [46]. This evidence concerns the gene KIT and Merkel cell skin cancer.