Given that the APC/C-BRD7 pathway plays key roles in cell growth and the tumorigenesis of osteosarcoma (Fig. 4), which has a poor prognosis because of chemoresistance [15], we investigated whether apoptosis induced by chemotherapeutic drugs could be enhanced by inhibiting the APC/C-BRD7 pathway in osteosarcoma. Here, APC is linked to osteosarcoma.