CDC20 and osteosarcoma: Interestingly, this up-regulation of BRD7 by the knockdown of Cdh1 or Cdc20 appears to be specific in osteosarcoma cell lines, including U2OS and its derivative line U2OS/MTX300, as well as SAOS2 and MG63 cells (Fig. 1D), because this phenomenon was not observed in other cell lines such as HeLa, HepG2, HCT116, MCF7 and CNE2 (Fig. S3).