For example, down-regulation of BRD7 was reported in nasopharyngeal carcinoma and prostate cancer, and its inhibition of cell growth probably occurs through transcriptional regulation of ras/MEK/ERK, Rb/E2F, beta-catenin, which in turn affects progression of the cell cycle [10-12]. This evidence concerns the gene MAP2K7 and nasopharyngeal carcinoma.