In this study, we found that APC/Ccdh1 and APC/Ccdc20 directly bind and degrade BRD7 (Figs. 1C, 2, and 3), a finding that is clinically relevant because a strong inverse correlation between the expression levels of BRD7 and Cdh1 or Cdc20 was observed in patients with osteosarcoma (Fig. 6B). Here, BRD7 is linked to osteosarcoma.