BRD7 and nasopharyngeal carcinoma: There are two possibilities, it is probably related to BRD7 localization in different cell types that depends on the post-translational modification of the protein[28]; BRD7 was mainly localized in the nuclei of nasopharyngeal carcinoma cells [10], whereas our IHC showed that BRD7 was mainly located in the cytoplasm of osteosarcoma tissue (Fig. 6A).