Since Plin-2 null mice are protected against diet induced obesity [90], these changes indicate SPR4 may influence fat-mass by; (1) inhibiting PHEX activity in WT mice and/or (2) sequestering and neutralizing excess ASARM-peptides in PHEX defective HYP-mice. The gene discussed is PHEX; the disease is obesity due to melanocortin 4 receptor deficiency.