MTOR and neoplasm: To investigate whether pharmacologic inhibitors of mTOR and DNA methylation may have therapeutic roles in all group 1 CNS-PNETs, we tested the effects of rapamycin as well pharmacologic inhibitors of DNA methyl transferase function (5-azacytidine and vorinostat), on growth of a tumor cell line (A664) derived from a non-C19MC amplified primary cerebral PNET398.