Subsequent genome wide association studies have identified 47 independently confirmed SLE variants, 57% of which map in or near type I IFN or 7 genes with known key roles in type I IFN production or signaling, including IRF5, IRF7, IRAK1, TNFAIP3, TNIP1, IFIH1, and TYK2 (reviewed in[29]). The gene discussed is IRF5; the disease is systemic lupus erythematosus.