S100A12 and hepatocellular carcinoma: In this study, we not only prove that the S100A12 and AMACR were associated with the recurrence/metastasis of H-HCC, but also clearly demonstrate that these two proteins have completely inverse expression profiles between the early (within 6 months, down regulated) and late (from 6 to 12 months, up regulated) recurrence/metastasis of H-HCC, even considering a larger “n” number of clinical samples as employed in this study.