CDH1 and orofacial cleft: The increased occurrence of cleft lip/cleft palate in HDGC patients with a CDH1 mutation was suggested by Frebourg et al. [12] and supported by Kluijt et al. [13], who have described 4/58 (7 %) CDH1 germline mutation carriers with orofacial cleft in the Dutch study for familial cancer.