The increased insulin sensitivity positively influenced the decrease in fasting plasma glucose and HFC (although the HbA1c level decreased comparably in both regimens) or, conversely, decreased HFC may have led to increased insulin sensitivity, because HFC is typically associated with insulin resistance (independent of BMI) [40], metabolic syndrome, type 2 diabetes and subclinical atherosclerosis [41]. This evidence concerns the gene INS and metabolic syndrome.