Network 3 was characterised by the insertion of a hub protein HNF4alpha, a transcription factor recently shown to play a role in other neoplasias [26] and Network 4 was characterised by numerous mitochondrial-localised proteins (CAT, IDH3A, NDUFS3 and other complex 1 proteins, OXCT1 and PRDX3). This evidence concerns the gene IDH3A and neoplasm.