12 of the 68 proteins altered in young GBM have previously been described altered in proteomic studies of glioma (APOA1, GFAP, HSPA5, PDIA3, TUBB2A, GLUD1, GSTP1, PGAM1, UCHL1, HSPB1, HSPD1 and SRI) [5]. This evidence concerns the gene HSPB1 and central nervous system cancer.