Based on the report that ARRB1 interacts with and regulates HIF1A activity in breast cancer cells and given the important role of HIF1A on metabolism and the critical role played by HIF1A in the progression of prostate cancer (Park et al, 2012), we have carried out a detailed study to determine the role of ARRB1 in prostate cancer cells using genomics and metabolomics. The gene discussed is ARRB1; the disease is prostate carcinoma.