The IL-6, TNF-α, and TGF-β were immunohistochemically detected in the glomeruli of STZ-induced type I diabetic mice repeatedly administered intraperitoneal Porphyromonas gingivalis LPS whereas no cytokines were detected in the kidneys of the diabetic mice without LPS (Fig. 8A) or in the non-diabetic mice with LPS (not shown). The gene discussed is IL6; the disease is type 1 diabetes mellitus.