In the laser-scanning confocal microscopy on the glomeruli of the STZ- and HF-induced diabetic mice, podoplanin-positive podocytes were not immunostained with anti-TLR2 while VE-cadherin and PECAM-1-positive glomerular endothelial cells were stained (Fig. 3, Fig. 4), and reaction products with anti-TLR2 were present at the inside of proximal tubule epithelial cells of HF-induced diabetic mice. Here, CDH5 is linked to hydrops fetalis.