There are renal cells expressing TLR2 in the human kidney with diabetic nephropathy and TLR2 expression was detected in almost all glomeruli of the type I and type II diabetic mouse kidneys here which showed glomerulosclerosis and edema, and detected in the type II diabetic mouse proximal tubules but not in the non-diabetic mouse kidneys (Fig. 1,2). The gene discussed is TLR2; the disease is glomerulosclerosis.