CDKN2A and neoplasm: SATB1 could upregulate the expressions of many genes which had critical roles in promoting tumor growth and metastasis (e.g. cell cycle progression-promoting gene CDK4, MMPs, Snail1and Slug), while many tumor suppressor genes (e.g. cell cycle arrest factors p16INK4A, promoting apoptosis gene FADD and epithelial markers E-cadherin) were significantly downregulated [19].