To investigate the phenomenon and mechanism of SATB1-mediated regulation on invasive and metastatic capacity of ccRCC, additional immunohistochemical staining were utilized to detect the levels of EMT markers (including E-cadherin, ZEB2, vimentin and fibronectin) and SATB2, a homologue of SATB1, and analyze the potential correlations between SATB1 and expressions of EMT markers or SATB2 in ccRCC tissues. The gene discussed is FN1; the disease is nonpapillary renal cell carcinoma.