SATB1 and cancer: In addition, Han et al examined expression of SATB1 in breast cancer cells by gene expression profiling, and described that knockdown of SATB1 mediated by specific RNA-interference in highly aggressive (MDA-MB-231) cancer cells significantly changed expression levels of over 1,000 genes, resulting in tumorigenesis reverse and growth and metastasis inhibition of breast tumor in vivo, and most of these genes were associated with cell adhesion, phosphatidylinositol signaling and cell cycle regulation [12].