In keeping with these findings, our data further revealed that depletion of SATB1 suppressed the proliferation and aggressiveness of renal cancer cells with higher invasive activities in vitro; on the contrary, ectopic introduction of SATB1 resulted in increased growth and aggressive phenotype of renal cancer cells, which was probably due to induction of EMT in vitro. Here, SATB1 is linked to renal carcinoma.