DRD3 and major depressive disorder: In the examination of single variant effects (see Table 4), we found that two individual variants were correlated with CES-D score: the DRD2/ANKK1 Lys (A1) allele (β = −1.6, p = 0.01), and the DRD3 Ser allele (β = −1.1 p = 0.06) were each individually associated with higher depression scores, though only DRD2/ANKK1 was statistically significant and remained so after adjusting for multiple comparisons using a Bonferroni-corrected α = 0.01.