The close contact between Nestin+ cells and capillaries [10] and the perivascular position of tumor stem cells recognizable by CD133 positivity or expression of specific stem cell antigens [13] correspond, from the neuropathological point of view, to the distribution of Nestin in gliomas that is less extensive than that of GFAP, but it includes more immature tumor cells, stem cells, and progenitors [15]. Here, NES is linked to central nervous system cancer.